The sterile insect technique is an environmentally friendly method to control and even eradicate insect pests. However, the continuous production and release of sterile insects is economically costly. In this study, we focus on the theory and empirical findings of interspecific negative mating interaction, known as reproductive interference, to develop a more cost-effective and value-added pest management program. We suggest that sterile insects can be used for simultaneous control of both wild-type conspecifics and closely related pest species by taking advantage of the fact that, when species recognition abilities are incomplete, courtship and mating are often misdirected toward heterospecies. In particular, we suggest that even weak reproductive interference would be effective to confine the number of host-plant (crop) species of generalist pests, which will in turn become a non-serious pest that specializes on a limited number of host species. This new approach might help mitigate economic damage and human health crises caused by pest insects in the world.