Humans have transformed the Earth’s surface so extensively that we are now a primary and global geomorphic agent. Habitat simplification, in particular, has strong and lasting effects on ecological communities as habitat diversity influences biodiversity, species distributions, movement, and life histories. Additionally, changes to the spatial arrangement and composition of habitat can rewire the architecture of species interaction networks that define patterns of energy flux, interaction strengths, and community stability. As such, uncovering relationships between habitat diversity and species interactions is crucial for predicting how ongoing land-use change and homogenization will influence biodiversity and human wellbeing. We used side-scan sonar technology to quantify the geophysical templet (defined here as the mosaic of main-channel benthic substrate types and off-channel habitats) of a large U.S. riverscape at a scope (ratio of extent to resolution) rarely achieved. We then sampled benthic communities and fish diets throughout the riverscape for a year to quantify habitat-specific invertebrate prey production, invertebrate diversity, and energy flows to the endangered Pallid Sturgeon (Scaphirhynchus albus) and the sympatric Shovelnose Sturgeon (Scaphirhynchus platorynchus). Finally, we simulated thousands of energetic food-web modules in a wide variety of habitat contexts (i.e., homogenous sand to diverse habitat mosaics) to examine how spatial variation in sturgeon foraging shapes distributions of trophic interaction strengths and potential food-web stability. We hypothesized that sturgeon foraging windows that include a high degree of habitat diversity would positively influence food-web stability by enhancing prey resource diversity and production, dispersing strong top-down predation across multiple habitats, and reducing strong and potentially destabilizing food-web interaction strengths. Our results demonstrate a clear relationship between habitat diversity and species interaction strengths, with more diverse foraging landscapes containing higher production of prey and a greater proportion of weak and potentially stabilizing interactions. Additionally, rare patches of large and relatively stable river sediments intensified these effects and further reduced interaction strengths by increasing prey diversity. Revealing life's “devious strategies” that underpin the persistence and stability of food webs is a long-standing endeavor in ecology and has emerged as a key conservation priority. Our findings highlight the importance of landscape heterogeneity in promoting stabilizing food-web architectures and provide direct relevance for future management of imperiled species in a simplified and rapidly changing world.